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Fig. 7 | BMC Veterinary Research

Fig. 7

From: Establishment of canine mammary gland tumor cell lines harboring PI3K/Akt activation as a therapeutic target

Fig. 7

Histopathological features of MGT612 cells through orthotopic injection in Xenograft mouse models. (A) Tumor volume of the nude mice. The data are shown as the mean ± SD, n = 3. (B) Picture of a MGT612 cell xenograft mouse with a tumor in the inguinal fata pad at nine weeks. (C) Tumor lesions were multi-lobulated and had severe locally extensive necrosis (asterisk) in the center. (D, E) The main tumor lesion was characterized by two different cell populations. (D) Malignant epithelial cells showed severe loss of tubule formation. (E) Spindle-shaped myoepithelial cells were arranged in irregular bundles with a fibrillar matrix. Scale bar = (C) 800 μm and (D, E) 50 μm. Mitotic figures (black arrowhead)

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BMC Veterinary Research

ISSN: 1746-6148

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