Hyaluronic acid impacts hematological endpoints and spleen histological features in African catfish (Clarias gariepinus)

Table 1 Histological lesion scoring for different dose exposure to hyaluronic acid

	Control	Low-dose (0.5 mg/l HA)		Medium-dose (10 mg/l HA)		High-dose (100 mg/l HA)
		Exposed	Recovered	Exposed	Recovered	Exposed	Recovered
Splenic necrosis	-	-	-	+	+	++	++
Melanomacrophage centers	-	+	+	++	++	+++	+++
Perivascular fibrosis	-	+	+	++	++	+++	+++
Thickened Trabeculae	-	-	-	++	++	+++	+++
Increased sinusoidal space	-	+	+	+	+	++	++
Neutrophilic infiltration	-	+	+	+	+	++	++
Clogged blood vessels	-	-	-	+	+	++	++
White pulp proliferation	-	-	-	+	+	++	++

(-) considered no change; (+) mild change; (++) moderate change; (+++) severe change

ISSN: 1746-6148