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Table 3 Safety evaluation for intravenous administration of canine allogenic adipose tissue-derived MSCs

From: Intravenous injection of allogenic canine mesenchymal stem cells in 40 client-owned dogs: a safety assessment in veterinary clinical trials

Case

Signalment

Underlying disease

Complication after MSC administration

Number of MSC administration

Follow-up period from MSC therapy (Months)

Subsequent tumorigenesis

1

11 year MC Poodle

DM

-

3

14

-

2

12 year FS Maltese

CKD

-

3

16

-

3

13 year FS Pomeranian

DM

-

4

11

-

4

9 year IF Shih-tzu

Chronic hepatitis

-

5

39

-

5

9 year FS Cocker spaniel

CKD

-

2

6

-

6

6 year IF Maltese

Protein losing enteropathy

-

5

25

-

7

13 year MC Yorkshire terrier

CKD, Proteinuria

-

10

21

-

8

6 year MC Cocker spaniel

AKI

-

4

6

-

9

12 year MC Mixed

MMVD

-

8

33

-

10

15 year FS Poodles

DM

-

3

6

-

11

11 year MC Mixed

DM

Vasculitis

5

15

-

12

10 year MC Shih-tzu

MMVD

-

3

35

-

13

13 year MC Maltese

CKD

-

7

20

-

14

9 year FS Poodles

Fanconi syndrome

-

11

29

-

15

16 year FS Miniature pinscher

CKD

-

2

6

-

16

8 year FS Maltese

MMVD

-

4

8

-

17

14 year IF Maltese

Hydrocephalus

-

3

12

-

18

8 year MC White terrier

AKI

-

5

8

-

19

14 year MC Maltese

CKD, Proteinuria

-

6

7

-

20

14 year FS Schnauzer

CKD

-

4

6

-

21

13 year IM Cocker spaniel

CKD

-

2

6

-

22

12 year MC Maltese

Hepatocutaneous syndrome

-

24

18

-

23

7 year IF Afghan hound

Immune mediated polymyositis

-

3

7

-

24

12 year FS Shih-tzu

Hepatocellular Carcinoma

-

51

28

-

25

2 year MC Yorkshire terrier

GME

-

5

6

-

26

12 year MC Shih-tzu

CKD

-

3

6

-

27

13 year MC Schnauzer

Chronic Hepatic Failure

-

4

6

-

28

10 year MC Afghan hound

Multicentric lymphoma

-

16

7

-

29

16 year FS Schnauzer

Chronic Hepatic Failure

-

9

10

-

30

11 year MC Yorkshire terrier

CKD

-

19

20

-

31

15 year FS Maltese

MMVD

Vasculitis

13

16

-

32

7 year FS Poodle

Inflammatory Bowel Disease

Vasculitis

3

14

-

33

13 year MC Pekingese

MMVD

-

2

10

-

34

15 year MC Shih-tzu

Multicentric lymphoma

-

2

7

-

35

11 year IF Poodle

CKD

-

2

24

-

36

11 year FS Old English Sheepdog

Liver cirrhosis

-

9

8

-

37

11 year MC Shih-tzu

Pemphigus foliaceus

-

11

36

-

38

10 year IM Shih-tzu

Alimentary lymphoma

-

27

32

-

39

8 year MC Maltese

Non-regenerative IMHA

-

5

6

-

40

16 year IF Maltese

CKD

-

7

10

-

  1. MC, male castrated; FS, female spayed; IM, intact male; IF, intact female
  2. DM, diabetes mellitus; CKD, chronic kidney disease; AKI, acute kidney injury; MMVD, myxomatous mitral valve disease; GME, granulomatous meningoencephalitis; IMHA, immune-mediated hemolytic anemia; MSC: mesenchymal stem cell
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BMC Veterinary Research

ISSN: 1746-6148

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