Table 2 Top 20 differentially common over-represented WCL proteins vs. healthy control in CMT cell lines

Accession number

Protein name

Protein abbreviation

ZMTH3 Log2FC

MTH52C

Log2FC

1305

Log2FC

DT1406TB

Log2FC

A0A8I3PIK8

Alpha-2-HS-glycoprotein

AHSG

3.875

7.537

7.181

5.387

A0A8I3NGU2

Folate_rec domain-containing protein

LOC476816

5.108

6.698

5.571

6.387

A0A8I3P8T5

Cysteine and glycine rich protein 1

CSRP1

5.776

2.430

8.488

6.356

A0A8I3N5K4

Peptidyl-prolyl cis-trans isomerase

PPIC

6.353

2.194

6.291

5.153

A0A8I3P375

Hook microtubule tethering protein 3

HOOK3

3.798

5.981

5.837

4.102

A0A8I3Q2T3

Reticulocalbin 1

RCN1

2.783

4.697

7.752

3.734

A0A8I3PW67

DLG associated protein 4

DLGAP4

1.708

4.136

6.593

4.383

Q38JA9

Caspase 8

CASP8

5.210

4.122

4.978

2.240

A0A8I3RP80

Nucleobindin-1

NUCB1

1.601

6.004

5.651

3.035

A0A8I3N5W9

Protein kinase domain-containing protein

RIPK3

3.977

3.259

4.929

3.830

A0A8I3MQM8

Prosaposin

PSAP

1.604

4.820

6.394

2.912

A0A8I3NTX2

Mitochondrial antiviral signaling protein

MAVS

2.310

4.379

6.169

2.631

A0A8I3P225

GLOBIN domain-containing protein

LOC609402

1.814

5.072

6.257

1.981

A0A8P0N4U0

Heme oxygenase

HMOX1

2.849

4.484

4.044

3.503

A0A8P0TML4

Ring finger protein 214

RNF214

2.850

5.212

3.562

3.099

A0A8I3MYL2

Mitochondrial trans-2-enoyl-CoA reductase

MECR

1.343

2.349

7.828

3.124

A0A8I3S1U2

Methyltransferase like 7 A

METTL7A

3.382

1.674

4.967

4.326

A0A8I3NUI7

Coatomer subunit zeta

COPZ2

2.575

2.756

4.486

4.503

A0A8I3MCD6

GLOBIN domain-containing protein

HBQ1

2.048

4.828

5.210

1.888

A0A8I3NVB0

Zyxin

ZYX

1.263

3.905

5.032

3.443

Common under-represented proteins

Accession number

Protein name

Protein abbreviation

ZMTH3

Log2FC

MTH52C

Log2FC

1305

Log2FC

DT1406TB

Log2FC

A0A8I3NQ76

Cytochrome P450 family 39 subfamily A member 1

CYP39A1

-7.634

-5.342

-7.234

-4.981

A0A8I3NB48

Stonin-2

STON2

-3.664

-4.148

-3.505

-2.718

A0A8I3RWC5

Pleckstrin homology and RhoGEF domain containing G4

PLEKHG4

-3.007

-5.073

-5.241

-0.623

A0A8I3RS96

Dermatopontin

DPT

-4.693

-3.372

-4.739

-1.009

A0A8I3PI43

Nucleolar complex protein 3 homolog

NOC3L

-0.736

-3.834

-5.105

-4.048

A0A8I3Q982

Interferon related developmental regulator 1

IFRD1

-2.863

-1.472

-5.130

-4.098

A0A8I3NKM0

tRNA dimethylallyltransferase

TRIT1

-1.911

-2.817

-4.625

-2.501

A0A8I3Q4 × 2

Ubiquitin specific peptidase 19

USP19

-1.888

-2.480

-4.484

-2.824

A0A8I3PIR4

Fibroblast growth factor 7

GALK2

-3.957

-2.692

-2.801

-2.029

A0A8I3N128

Cyclin dependent kinase 2

CDK2

-0.388

-0.379

-7.813

-2.540

A0A8I3RUT0

rRNA adenine N(6)-methyltransferase

DIMT1

-1.667

-2.422

-5.646

-1.383

A0A8I3NJG0

TatD DNase domain containing 1

TATDN1

-2.207

-1.452

-4.510

-2.850

A0A8I3P8U7

Cms1 ribosomal small subunit homolog

CMSS1

-0.995

-2.899

-4.866

-2.214

A0A8I3NFP5

Neurobeachin like 2

NBEAL2

-2.744

-3.091

-3.938

-1.134

A0A8I3PB80

Hyaluronidase 3

HYAL3

-2.310

-2.229

-4.172

-2.080

A0A8I3PRT9

Inosine-5’-monophosphate dehydrogenase

IMPDH1

-3.233

-1.501

-4.005

-1.938

A0A8I3Q7R1

Inosine-5’-monophosphate dehydrogenase

IMPDH2

-2.070

-0.621

-4.916

-2.830

A0A8P0NPZ9

Pleckstrin homology domain containing A2

PLEKHA2

-4.354

-1.288

-2.812

-1.972

A0A8I3S0T5

CCAAT enhancer binding protein zeta

CEBPZ

-1.140

-4.729

-3.102

-1.406

A0A8P0NM37

ACD shelterin complex subunit and telomerase recruitment factor

ACD

-1.818

-1.722

-4.163

-2.623