Table 5 Top 20 differentially common under-represented EV proteins vs. healthy control in CMT cell lines

Accession number

Protein name

Protein abbreviation

ZMTH3 Log2FC

MTH52C

Log2FC

1305

Log2FC

DT1406TB

Log2FC

A0A8I3NTB5

Galectin-3-binding protein

CANT1

8.065

3.700

12.760

9.220

A0A8P0N757

Serine protease 23

PRSS23

6.058

3.657

8.085

8.682

A0A8I3Q308

Olfactomedin like 2B

OLFML2B

1.900

5.182

7.641

9.408

A0A8I3P684

Lumican

LUM

2.505

11.155

1.433

8.507

A0A8I3PKT4

Complement C1s

C1S

4.888

4.440

9.560

3.265

A0A8I3N2B1

Beta-1,3-N-acetylglucosaminyltransferase

LFNG

2.676

4.905

7.775

6.669

A0A8I3QK41

Pirin

PIR

1.312

3.451

4.550

8.350

A0A8I3S0C0

Lysyl oxidase homolog

LOXL3

0.979

2.957

7.004

6.529

A0A8I3PRC1

Semaphorin-3 C

SEMA3C

3.698

1.429

5.501

4.237

A0A8I3MTX4

Matrix metallopeptidase 19

MMP19

3.141

3.013

3.129

4.508

A0A8I3MIR7

Lysophosphatidylcholine acyltransferase 2

LPCAT2

0.925

2.086

3.281

7.370

A0A8I3PN55

BRO1 domain-containing protein

PDCD6IP

1.429

3.837

5.822

2.288

A0A8I3S0A8

Tripartite motif containing 25

TRIM25

3.737

2.188

4.888

1.959

A0A8P0NAE9

Calpastatin

CAST

1.081

3.637

5.163

2.655

A0A8I3NB75

Thrombospondin 2

THBS2

1.132

0.915

2.530

7.351

A0A8I3PVI8

LRR binding FLII interacting protein 2

LRRFIP2

1.281

1.685

2.837

6.001

A0A8P0TPH1

Ras-related protein Rab-4

RAB4A

2.203

2.294

3.509

2.816

Q38JA9

Caspase 8

CASP8

1.839

1.735

2.756

3.669

A0A8I3Q6P2

Progesterone receptor membrane component 2

PGRMC2

1.278

0.761

4.155

3.248

P06625

Signal recognition particle receptor subunit alpha

SRPRA

2.452

1.162

3.140

2.625

Common under-represented proteins

Accession number

Protein name

Protein abbreviation

ZMTH3

Log2FC

MTH52C

Log2FC

1305

Log2FC

DT1406TB

Log2FC

A0A8P0SLL9

Exportin 6

XPO6

-1.488

-5.010

-7.770

-6.686

A0A8I3NJG0

TatD DNase domain containing 1

TATDN1

-3.524

-1.490

-5.855

-3.802

A0A8I3MMH6

Chromosome 4 C5orf22 homolog

C4H5orf22

-2.712

-2.001

-3.975

-4.296

A0A8I3PRT9

Inosine-5’-monophosphate dehydrogenase

IMPDH1

-3.416

-2.789

-4.010

-1.788

A0A8I3Q4 × 2

Ubiquitin specific peptidase 19

USP19

-0.530

-1.699

-3.658

-5.477

A0A8I3QXV7

GDP-mannose pyrophosphorylase A

GMPPA

-0.529

-2.945

-3.164

-4.572

A0A8I3MYE7

Regulation of nuclear pre-mRNA domain-containing protein

RPRD1A

-3.296

-1.052

-4.263

-2.261

A0A8I3S4H8

Adenosylhomocysteinase like 2

AHCYL2

-2.212

-2.263

-4.242

-1.195

A0A8I3PIR4

Fibroblast growth factor 7

GALK2

-1.182

-1.436

-1.055

-5.984

A0A8I3NSZ0

Argininosuccinate lyase

GUSB

-1.617

-1.238

-3.938

-2.246

A0A8P0NK55

Dipeptidyl peptidase 9

DPP9

-2.086

-1.861

-3.587

-1.368

A0A8I3MP00

TIP41-like protein

TBX19

-0.767

-0.800

-4.802

-2.381

A0A8P0TU84

Core-binding factor subunit beta

CBFB

-1.526

-0.825

-3.184

-3.002

A0A8I3PTA7

Dihydrolipoyl dehydrogenase, mitochondrial

DLD

-2.055

-2.534

-2.086

-1.690

A0A8I3Q7R1

Inosine-5’-monophosphate dehydrogenase

IMPDH2

-1.877

-1.302

-3.304

-1.716

A0A8I3NZF6

ATPase GET3

GET3

-0.356

-0.947

-3.553

-2.850

A0A8I3PVF4

Methylthioribose-1-phosphate isomerase

MRI1

-0.989

-2.024

-1.683

-2.792

A0A8I3N997

Polyadenylate-binding protein

PABPC4

-2.455

-1.357

-1.701

-1.906

A0A8I3PG05

Mevalonate kinase

MVK

-0.321

-1.320

-3.876

-1.746

A0A8P0TF63

Pseudouridine synthase 7

PUS7

-1.685

-0.915

-2.967

-1.626