Table 6 Top 20 differentially common over-represented EV proteins vs. healthy control in the carcinoma cell lines

Accession number

Protein name

Protein abbreviation

MTH52C

Log2FC

1305

Log2FC

DT1406TB

Log2FC

A0A8I3NGU2

Folate_rec domain-containing protein

LOC476816

7.242

8.684

9.315

A0A8P0TLW8

Scavenger receptor cysteine rich family member with 5 domains

SSC5D

8.289

10.690

5.018

Q28275

Fibronectin (Fragment)

FN1

4.837

6.517

10.712

A0A8P0SNB9

Biglycan

BGN

4.906

7.438

8.390

A0A8I3PAS0

Hyaluronan and proteoglycan link protein 1

HAPLN1

6.534

2.065

11.965

A0A8I3MGS0

72 kDa type IV collagenase

MMP2

3.103

6.260

8.838

A0A8I3Q318

Complement factor I

CFI

3.497

4.469

8.752

A0A8I3MZE8

GM2 ganglioside activator

GM2A

4.393

5.453

6.426

A0A8I3PHI4

Fibronectin

FN1

3.907

4.087

7.910

A0A8I3PMB5

Secretogranin-3

SCG3

4.982

2.825

7.256

A0A8I3PPU8

Thrombospondin 1

THBS1

1.870

7.201

5.508

A0A8P0P6 × 6

Cadherin-2

CDH2

2.801

4.917

5.930

A0A8I3Q5D9

Procollagen C-endopeptidase enhancer 2

PCOLCE2

2.813

3.477

7.098

A0A8I3MTJ9

Laminin subunit gamma 1

LAMC1

3.385

5.938

3.625

A0A8I3PM12

L1 cell adhesion molecule

L1CAM

1.683

7.241

3.972

A0A8I3PNM0

G_PROTEIN_RECEP_F3_4 domain-containing protein

GPRC5D

1.755

6.742

3.767

A0A8P0TM99

Pleckstrin homology like domain family B member 2

PHLDB2

2.235

6.263

3.720

A0A8P0SGF7

Hyaluronan and proteoglycan link protein 3

HAPLN3

3.031

3.779

5.017

A0A8I3NXQ5

Ethylmalonyl-CoA decarboxylase

3 SV

1.567

4.820

5.429

A0A8I3S4E2

Versican

VCAN

1.607

4.248

5.805

Common under-represented proteins

Accession number

Protein name

Protein abbreviation

MTH52C

Log2FC

1305

Log2FC

DT1406TB

Log2FC

A0A8I3Q193

Selenocysteine lyase

SCLY

-1.972

-5.637

-5.324

A0A8I3NJ98

N-sulfoglucosamine sulfohydrolase

SGSH

-2.091

-4.984

-4.477

A0A8I3QBZ4

Taxilin gamma

TXLNG

-0.878

-4.915

-5.585

A0A8P0SNX6

tRNA: m(4)X modification enzyme TRM13

TRMT13

-2.591

-5.158

-3.569

A0A8P0TLB2

UBX domain-containing protein 7

UBXN7

-2.140

-4.895

-3.880

A0A8I3MKV2

Malignant T-cell-amplified sequence

LOC487150

-2.309

-4.124

-3.935

A0A8I3PUG8

TATA-box binding protein

TBP

-2.315

-3.893

-4.015

A0A8I3RWI4

Section 1 family domain containing 2

SCFD2

-2.539

-2.898

-4.163

A0A8I3PMJ4

DIS3-like exonuclease 2

DIS3L2

-3.638

-2.854

-2.612

A0A8I3N7E1

CTP synthase

CTPS1

-2.172

-3.350

-3.558

A0A8I3MKB3

CYRIA-B_Rac1-bd domain-containing protein

CYFIP2

-2.791

-3.719

-2.455

A0A8I3RYJ8

Lysine demethylase 2 A

KDM2A

-0.797

-4.070

-4.012

A0A8I3RXS7

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

DPH1

-2.365

-2.992

-3.444

A0A8I3RW28

ASPSCR1 tether for SLC2A4, UBX domain containing

ASPSCR1

-1.848

-4.301

-2.302

A0A8I3RX66

thioredoxin-disulfide reductase

TXNRD3

-1.867

-4.939

-1.281

A0A8I3NN15

Small nuclear ribonucleoprotein Sm D1

SNRPD1

-0.857

-4.393

-2.586

A0A8P0NJW0

Metastasis associated 1

MTA1

-1.104

-4.682

-1.985

A0A8I3S647

Propionyl-CoA carboxylase alpha chain, mitochondrial

PCCA

-2.235

-3.662

-1.763

P10463

Calcyphosin

CAPS

-1.802

-2.734

-2.894

A0A8P0SK07

Complement component 1 Q subcomponent-binding protein, mitochondrial

C1QBP

-0.944

-3.812

-2.622