Table 1 Histopathological grades of the brain (cerebrum) and lumbar spinal cord in suckling mice inoculated with DMEM, wild type, and rescued AKAVs (± , minimal; + , mild; -, without histopathological alterations)

Brain

Gliosis

 ± 

0

0

1^a

1^f

2 ^{k, l}

 + 

0

0

0

0

0

Neutrophil inflammation, in perivacular and neuronal area

 ± 

0

0

1^b

2 ^{g, h}

2 ^{k, l}

 + 

0

0

0

1i

0

Necrosis, neuronal

 ± 

0

0

1^a

0

0

none

-

5

5

2^{d, e}

1^j

3 ^{m, n, o}

Spinal Cord

Gliosis

 ± 

0

0

0

1 ^g

1 ^l

 + 

0

0

1^a

0

1 ^m

Neutrophil inflammation, in perivacular and neuronal area

 ± 

0

0

0

1^j

2 ^{l, m}

 + 

0

0

1^c

0

0

Necrosis, neuronal

 ± 

0

0

1^c

0

0

none

-

5

5

2^{d, e}

3^{i, f, h}

3 ^{k, n, o}