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Fig. 4 | BMC Veterinary Research

Fig. 4

From: Isolation and characterization of bovine coronavirus variants with mutations in the hemagglutinin-esterase gene in dairy calves in China

Fig. 4

One-step growth curve analysis. (a) HRT-18 cell were infected with the HE-insertion variant (B298-HE428) and HE non-variant (B277a-HE424) showing CPE at 72 h, while the HE-deletion variant (B277b-HE420) showed non-CPE. (b) Growth kinetics of the HE-insertion variant (B298-HE428), HE-deletion variant (B277b-HE420), and HE non-variant (B277a-HE424) were depicted by one-step growth curve. The HRT-18 cells were infected with 1 MOI virus. Cell culture was harvested at 12 h interval and TCID50 was calculated. The mean values with standard deviations of three independent experiments were calculated. *, P < 0.05; **, P < 0.01, compared with the HE non-variant (B277a-HE424)

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BMC Veterinary Research

ISSN: 1746-6148

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