Allelic frequency of 12-FGF4RG and the association between the genotype with number of calcified intervertebral discs visible on radiographs in Coton de Tuléar and French Bulldog breeds

Table 3 Effect of different 12-FGF4RG genotypes on number of CDVR and IDC grade 3 as Poisson regression estimates for number of CDVR and cumulative logit-model odds ratios for probability for having IDC grade 3 in Coton de Tuléar

Variable	*12-FGF4***RG	Estimate	Lower CI	Upper CI	P-value
	homozygous vs. heterozygous	4.88	3.99	5.96	<0.0001
Estimates for higher number of CDVR	homozygous vs. wild-type	36.67	21.82	61.63	<0.0001
	heterozygous vs. wild-type	7.52	4.42	12.81	<0.0001
	*12-FGF4***RG	OR	Lower CI	Upper CI	P-value
	homozygous vs. heterozygous	15.34	6.78	34.7	<0.0001
Odds ratios for probability of IDC grade 3	homozygous vs. wild-type	92.45	33.51	255	<0.0001
	heterozygous vs. wild-type	6.02	2.76	13.12	<0.0001

12-FGF4RG, FGF4 retrogene insertion in chromosome 12; CDVR calcified discs visible on radiographs; IDC grade 3 severe intervertebral disc calcification based on number of CDVR; OR odds ratio; CI 95% confidence interval

ISSN: 1746-6148