Table 2 Detection of single nucleotide polymorphisms in four canine mast cell tumour cell lines

C-kit

Chr13:47,175,092

rs22299980 A > G

G

CMMC

VIMC, CoMS

p.Thr425 =

nonsense

AG

C18

-

p.Asn426GlufsTer25

frameshift

A

wildtype

HYAL4

Chr14:11,778,977

rs8499846 G > A

A

C18

-

upstream gene variant

upstream gene variant

GA

CMMC

CoMS

G

wildtype

Chr14:11,791,385

14:11791385 A > G

G

-

VIMC

intergenic variant

intergenic variant

GA

C18, CMMC

CoMS

A

wildtype

Chr14:11,794,735

14:11794735 C > T

T

-

VIMC

intergenic variant

intergenic variant

CT

C18, CMMC

CoMS

C

wildtype

POT1

Chr14:11,033,763

c.927delT

Del

-

VIMC

p.Phe309LeufsTer3

frameshift

T

wildtype

SEL1L

Chr8:53,778,185

8:53778185 T > C

C

-

VIMC

intron variant

intron variant

CT

C18, CMMC

CoMS

T

wildtype

Chr8:53,785,948

8:53785948 A > G

GA

CMMC

-

intron variant

intron variant

A

wildtype

Chr8:53,796,442

rs24507594 A > G

G

C18, CMMC

-

intron variant

intron variant

A

wildtype

Chr8:53,818,371

8:53818371 G > A

A

C18, CMMC

-

intron variant

intron variant

G

wildtype

Chr8:52,763,337

rs24560262 C > A

CA

-

CoMS

intergenic variant

intergenic variant

C

wildtype

SPAM1

Chr14:11,704,952

rs851582160 T > C

TC

C18, CMMC

VIMC, CoMS

p.Lys482ArgfsTer27

frameshift

T

wildtype

TRAF3

Chr8:70,782,945

rs851689319 A > T

T

-

VIMC, CoMS

p.Lys284Ter

nonsense

AT

C18

-

p.Lys284IlefsTer14

frameshift

A

wildtype

Chr8:70,782,999

c.906delT

Del

-

VIMC

p.Ile302MetfsTer21

frameshift

T

wildtype

Chr8:70,783,003

c.908dupA

A

-

CoMS

p.Arg304GlufsTer9

frameshift

Del

wildtype