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Table 1 Pharmacokinetic (PK) parameters of AMX after single oral administration AMX-CA 250 mg either formulation A or formulation B in dogs (Mean ± SD, n = 6)

From: Comparative bioavailability study of two oral formulations of amoxicillin-clavulanic acid in healthy dogs

PK Parameter

Unit

AMX-CA 250 mg formulations

Formulation A

Formulation B

Cmax

µg/mL

6.58 ± 1.37a

4.79 ± 0.97

Tmax

h

1.50 ± 0.00

1.67 ± 0.24

t1/2

h

1.80 ± 0.15

1.82 ± 0.19

kel

1/h

0.39 ± 0.03

0.39 ± 0.04

AUC0–12

µg∙h/mL

20.31 ± 5.33

15.28 ± 2.89

AUC0-∞

µg∙h/mL

20.59 ± 5.37

15.48 ± 2.92

  1. Cmax peak plasma concentration, Tmax time to achieve peak concentration, t1/2 elimination half-life, kel elimination rate constant, AUC0-12 area under the plasma concentration versus time curve from 0 to 12 h (the last measurable timepoint), AUC0-∞ area under the plasma concentration versus time curve extrapolated to infinity
  2. asignificant difference between columns (p < 0.05)
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BMC Veterinary Research

ISSN: 1746-6148

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