Comparative bioavailability study of two oral formulations of amoxicillin-clavulanic acid in healthy dogs

BMC Veterinary Research

Table 3 Bioequivalence analysis for natural log- transformed AUC_0-∞ and C_max of two AMX-CA oral formulations (n = 6)

Substance	PK Parameter	Unit	Geometric mean		Geometric mean ratio (90% CI)
Substance	PK Parameter	Unit	Formulation A	Formulation B	Geometric mean ratio (90% CI)
	C_max	µg/mL	6.44	4.68	0.73 (0.68–0.76)
AMX	AUC_0-∞	µg∙h/mL	19.90	15.22	0.77 (0.68–0.89)
	RBA	%	76.50
	C_max	µg/mL	1.21	1.09	0.90 (0.86–0.94)
CA	AUC_0-∞	µg∙h/mL	2.76	2.01	0.73 (0.69–0.77)
	RBA	%	72.70

C_max peak plasma concentration, AUC_0-∞ area under the plasma concentration versus time curve extrapolated to infinity. RBA relative oral bioavailability, CI confident interval

ISSN: 1746-6148