Histopathologic evaluation of skin wound healing due to local application of transdermal chitosan patch in combination with doxycycline, zinc nanoparticles, and selenium nanoparticles in mice

Table 4 Comparison of histological parameters in different groups on day 14 of the study

Group	Inflammation	Hemorrhage	Angiogenesis	orientation of collagen fibers	Re-epithelialization
Control	2 (2–3)^a	1 (1–2)^a	0 (0–1)^a	0 (0–1)^a	1 (1–2)^a
CsD	1 (1–2)^b	0 (0–1)^b	0 (0–1)^a	1 (1–2)^a	1 (1–2)^a
CsDZn	1 (0–1)^b	0 (0–1)^b	0 (0–1)^a	1 (0–2)^a	2 (1–2)^a
CsZnS	1 (1–2)^b	0 (0–1)^b	0 (0–1)^a	1 (1–2)^a	2 (1–2)^a
CsDZnS	0 (0–1)^c	0 (0–1)^b	0 (0–1)^a	1 (1–2)^b	2 (2–3)^b

Different letters indicate significant differences in each column (P˂0.05); CsD (chitosan containing doxycycline patch); CsDZn (chitosan containing doxycycline and zinc nanoparticles patch): CsZnS (chitosan containing doxycycline and selenium nanoparticles patch); CsDZnS (chitosan containing doxycycline and zinc nanoparticles, and selenium nanoparticles patch)

ISSN: 1746-6148