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Fig. 5 | BMC Veterinary Research

Fig. 5

From: Lumpy skin disease virus ORF142 protein inhibits type I interferon production by disrupting interactions of TBK1 and IRF3

Fig. 5

Schematic diagram of the working model of the LSDV ORF142 protein negatively regulating IFN-I production. The LSDV ORF142 protein inhibits the phosphorylation of IRF3 by interacting with IRF3 and disrupting the interaction between TBK1 and IRF3, thereby inhibiting the production of IFN-I. Both wild-type LSDV and ORF142 proteins allow the virus to evade innate immunity by inhibiting the binding of TBK1 and IRF3. The diagram was created using Figdraw (https://www.figdraw.com/)

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BMC Veterinary Research

ISSN: 1746-6148

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