Table 2 Characteristics of studies included in this review
Last name first author, publication year | Â | Rogers, 1988 (Amikacin) | Rogers, 1988 (Trimethoprim Sulfamethoxazole) | Mann, 1990 | Turnwald, 1986 |
|---|---|---|---|---|---|
General Information | Study design | Randomized controlled trial | Randomized controlled trial | Abstract, Experimental trial (randomization not fully described) | Randomized controlled trial |
Country and setting | United States, laboratory animals | United States, laboratory animals | United States, laboratory animals | United States, laboratory animals | |
Antibiotic comparison short arm | Single dose of amikacin treatment | Single dose of trimethoprim sulfadiazine treatment | Three-days of amoxicillin therapy | Single dose of trimethoprim sulfadiazine therapy | |
Antibiotic comparison long arm | Three days of amikacin treatment | Three days of trimethoprim sulfadiazine treatment | Fourteen days of amoxicillin therapy | Twenty-one days of trimethoprim sulfadiazine therapy | |
Population and disease details | Species | Dogs | Dogs | Cats | Dogs |
Total number of animals included in both short and long arms (sex) | 12 mixed breed dogs (6 males and 6 females) | 12 mixed breed dogs (6 males and 6 females) | 12 cats (6 males, 6 females*) | 18 mixed-breed female dogs | |
Health status of animals | Health status was assessed by physical exam, complete blood count, biochemistry fecal float and complete urinalysis | Health status was assessed by physical exam, complete blood count, biochemistry fecal float and complete urinalysis | Described as healthy | Described as healthy - a physical examination, urinalysis, and quantitative urine culture were done on each dog | |
Urinary tract infection details (experimentally induced vs. sporadic) | Induced | Induced | Induced | Induced | |
Primary outcomes and measures | Outcome measure (clinical or microbiological cure) | Microbiological cure | Microbiological cure | Microbiological cure | Microbiological cure |
Urine collection method | Urethral catheterization | Urethral catheterization | Not specified | Cystocentesis | |
Secondary outcomes | Long term cure rate(s), adverse events | None reported | None reported | None reported | None reported |
Risk of Bias | Overall risk of bias | High | High | Serious | High |