Fig. 1

Pathological features of PiAdV-1-infected pigeons. (A-D) Gross pathology: (A) Hepatic swelling with multifocal hemorrhages and capsular fragility. (B) Intrahepatic unclotted blood (black arrows) indicative of coagulopathy. (C) Hydropericardium and myocardial discoloration. (D-I) Histopathology (H&E staining): (D) Liver: Hepatocellular necrosis and basophilic intranuclear inclusion bodies. (E) Liver: Necrotic vascular endothelium. (F) Heart: Cardiomyocyte degeneration. (G) Kidney: Tubular epithelial necrosis. (H) Spleen: Lymphocyte depletion. (I) Jejunum: Villous epithelial necrosis. Yellow arrows indicate basophilic intranuclear inclusion bodies in the nuclei of infected cells