Fig. 3

Pathogenicity analyses. A: Survival rates of mice nasal drop infected with PmCQ2 and Δfis, respectively, n = 8 mice/group. B: Concentrations of IL-1β, IL-6, and TNF-α in the lung of mice after infection. C: Bacterial loads of lungs, livers, and spleens with PmCQ2, Δfis, C-fis and O-fis in mice. D: Macrophage engulfment of bacteria and proportion of adherent phagocytic bacteria. All data are expressed as mean ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001; ns means no significant